{"id":494,"date":"2025-07-30T14:34:04","date_gmt":"2025-07-30T14:34:04","guid":{"rendered":"https:\/\/template5.thinkcreativeintelligence.com\/?page_id=494"},"modified":"2025-08-27T23:43:14","modified_gmt":"2025-08-27T23:43:14","slug":"summary-of-studies","status":"publish","type":"page","link":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/summary-of-studies\/","title":{"rendered":"Summary of Studies"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"494\" class=\"elementor elementor-494\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-56e6047e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"56e6047e\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2043a02\" data-id=\"2043a02\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37ed7bcd elementor-widget elementor-widget-heading\" data-id=\"37ed7bcd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Summary of Studies<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6577718f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6577718f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-37ac3f05\" data-id=\"37ac3f05\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-468c9774 elementor-widget elementor-widget-elementskit-heading\" data-id=\"468c9774\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Studies in down-regulating MMP levels<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider ekit-dotted\"><div class=\"elementskit-border-divider ekit-dotted\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-568d0318 elementor-widget elementor-widget-text-editor\" data-id=\"568d0318\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Regenerex QBx\u2122 technology helps to normalize the micro-environment of wound beds by reducing protease levels, including MMP levels. This also applies to preceding generation PHI\u2122 technology referenced in some studies.<\/p><p>Once the wound bed\u2019s microenvironment is normalized, the body\u2019s normal, natural healing process is able to regenerate and rebuild tissues in the wound.<\/p><p>The following are studies conducted to observe the impact of lowering protease levels using protease down-regulating technology.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-795b584d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"795b584d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6208c715\" data-id=\"6208c715\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-100f5549 elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"100f5549\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/template5.thinkcreativeintelligence.com\/wp-content\/plugins\/elementor\/assets\/css\/widget-icon-list.min.css\">\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Studied Non-responsive Wounds<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Studied Wound Composition<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Studied Healing Processes<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-42a2f9b4\" data-id=\"42a2f9b4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1431cd98 elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"1431cd98\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Studied Protease Levels<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Documented Efficacy and Healing Times<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-2bc1bd2e elementor-widget elementor-widget-spacer\" data-id=\"2bc1bd2e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-645d5475 elementor-widget elementor-widget-elementskit-heading\" data-id=\"645d5475\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">A Randomized Double-Blind Study to Evaluate the Effects of MMP Down Regulators, on Two Different Topical Preparations, on the Healing of Partial Thickness Wounds in Healthy Human Volunteers.  <\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-329b2242 elementor-widget elementor-widget-text-editor\" data-id=\"329b2242\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"study-box\"><h5 dir=\"ltr\">Alvarez Study<\/h5><p dir=\"ltr\">A computer generated randomized table was used to assign one of four treatment regimens. These included a placebo, non-treated dressing, active ingredient in emulsion at 1.17% and active ingredient in emulsion at 4.88%. Wounds were clinically evaluated for epithelialization, granulation, exudate production, erythema, edema induration, reinjury, and pain level (upon application of the test agent and throughout the course of treatment).\u00a0<\/p><p dir=\"ltr\">The study shows higher concentration of the active ingredient to be the most effective in healing wounds in healthy human subjects in all clinical categories evaluated.\u00a0<\/p><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d0adea elementor-widget elementor-widget-spacer\" data-id=\"4d0adea\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5628e9b elementor-widget elementor-widget-elementskit-heading\" data-id=\"5628e9b\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Art of Balancing the Wound Micro-Environment: How to Treat Chronic Wounds in Another Way<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-666fa5f elementor-widget elementor-widget-text-editor\" data-id=\"666fa5f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"study-box\"><h5 dir=\"ltr\">Hoekstra Study<\/h5><p dir=\"ltr\">This study is a semi-comprehensive compilation of the wound healing process and treatments for chronic wounds. Included were a look into the healing process, the characteristics of non-responding wounds, various causes of non-responding wounds, and protocols for treating these wounds. The study discusses the importance of MMP\u2019s in the healing process and their role in contributing to non-responsive wounds if they are not down regulated as needed.\u00a0<\/p><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b27b08 elementor-widget elementor-widget-spacer\" data-id=\"5b27b08\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56683ab elementor-widget elementor-widget-elementskit-heading\" data-id=\"56683ab\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">An Observational Study of the Use of QBx\u2122 Impregnated Dressing in the Treatment of Wounds <\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ab1400e elementor-widget elementor-widget-text-editor\" data-id=\"ab1400e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"study-box\"><h5 dir=\"ltr\">Tissue Viability Consultancy Services, Ltd. Study<\/h5><p dir=\"ltr\">This clinical study was based on a series of case studies and is not strictly based on research principles. The overall aim was to demonstrate how the products containing QBx\u2122 can be used in general, and on hard-to-heal wounds, in order to rebalance MMPs through normalization of the wound micro-environment. Healing in \u201creal life\u201d wounds cannot be shown through randomized controlled trials, as the inclusion\/exclusion criteria are so strict that it excludes the wound types that are currently causing difficulties with healing in the community. In these case studies, there was an overall healing rate of 48% of those wounds treated with QBx\u2122 products and a predicted potential for a 72% healing rate.<\/p><p dir=\"ltr\">The cost effectiveness of QBx\u2122 products is without doubt. A 72% healing rate means that in 72% of the cases, cost savings are 100%.\u00a0 The QBx\u2122 products have been well accepted by both the patients and the healing rates are shown to be excellent in all these extremely difficult to heal wounds.\u00a0<\/p><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50e490d elementor-widget elementor-widget-spacer\" data-id=\"50e490d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a7eb7e elementor-widget elementor-widget-elementskit-heading\" data-id=\"1a7eb7e\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">The Use of QBx\u2122 Dressings on Hard to Heal Wounds<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fbfdf4 elementor-widget elementor-widget-text-editor\" data-id=\"4fbfdf4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"study-box\"><h5 dir=\"ltr\">Hendrix Study<\/h5><p dir=\"ltr\">This study provided visual documentation of clinical efficacy of MMP down-regulators on six different Stage III and Stage IV foot wounds. Five of the six wounds were healed in approximately three months, with only one wound requiring six months.<\/p><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49f1acd elementor-widget elementor-widget-spacer\" data-id=\"49f1acd\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-791a13f elementor-widget elementor-widget-elementskit-heading\" data-id=\"791a13f\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">3M studies<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b5ee073 elementor-widget elementor-widget-text-editor\" data-id=\"b5ee073\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"study-box\"><p>QBx\u2122 products have been well accepted by both the patients and the Health Care Professionals and the healing rates are shown to be excellent in all these extremely difficult to heal wounds.<\/p><p>\u00a0<\/p><p dir=\"ltr\"><strong>Briggs Study<\/strong><\/p><p dir=\"ltr\">Briggs S. \u201cClinical experience of a new wound dressing (DerMax\u00ae * PHI-5) in the local treatment of chronic leg ulcers.\u201d Wounds UK, Harrogate, November 2005, poster presentation.<\/p><p dir=\"ltr\">Leg ulcers\u00a0Under compression \/without compression<br \/>\u2022 Healing time<\/p><p dir=\"ltr\">Case studies<\/p><p dir=\"ltr\">1) 81-year-old patient, ulcer (3.5 cm x 3 cm) present for four months. Tegaderm\u2122 Matrix and compression therapy, wound dressed at weekly intervals when compression was changed. Healing of previously-unhealed ulcer occurred after 14 weeks of Tegaderm\u2122 Matrix therapy.<\/p><p dir=\"ltr\">2) 69-year-old patient, ulcer present for over two years. Tegaderm\u2122 Matrix and secondary dressing (patient did not tolerate compression), wound dressed at three-day intervals. Healing of previously-unhealed ulcer occurred after 16 weeks of Tegaderm\u2122 Matrix therapy.<\/p><p dir=\"ltr\">\u00a0<\/p><\/div><p dir=\"ltr\"><strong>K\u00f6rber Study<\/strong><\/p><p dir=\"ltr\">K\u00f6rber A et al. \u201cSuccessful treatment of therapy-refractory non-responding chronic wounds with DerMax\u00ae.\u201c European Wound Conference, Stuttgart, September 2005, poster presentation. Publication data.<\/p><p dir=\"ltr\">K\u00f6rber A et al. \u201cSuccessful treatment of therapy-refractory non-responding chronic wounds with DerMax\u00ae.\u201c J Wound Healing, Number 6, 2006, Zeitschrift fur Wundheiling.<\/p><p dir=\"ltr\">Chronic leg ulcers\u00a0\u2022 Wound size reduction<br \/>\u2022 Pain reduction<br \/>\u2022 Granulation and re-epithelialisation<br \/>\u2022 Overall assessment<\/p><p dir=\"ltr\">A total of five patients with venous leg ulcers were recruited. Tegaderm\u2122 Matrix treatment reduced wound size by 80% within the documented 10-week observation period and pain was reduced from 1.4 to 0.4 (on a pain scale of 0-5). Promotion of both granulation and epithelialization were observed. Final assessment of Tegaderm\u2122 Matrix treatment was rated as \u2018very good\u2019 or \u2018good\u2019. No side effects were observed.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2068dc elementor-widget elementor-widget-spacer\" data-id=\"c2068dc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b887f9b elementor-widget elementor-widget-elementskit-heading\" data-id=\"b887f9b\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Additional Studies<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-429ef27 elementor-widget elementor-widget-text-editor\" data-id=\"429ef27\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p dir=\"ltr\"><strong>Karim Study<\/strong><\/p><p dir=\"ltr\">Karim RB et al. \u201cMMP-2 assessment as an indicator of wound healing: a feasibility study.\u201d Adv Skin Wound Care, Vol 19, 2006, pp 324-327.<\/p><p dir=\"ltr\">Non-healing wounds\u00a0\u2022 MMP-2 expression<br \/>\u2022 Wound healing<\/p><p dir=\"ltr\">Phase II feasibility study of four patients with non-healing wounds. Wound duration &gt;three months, surface are &gt;1 cm2. Wounds treated daily with 3M\u2122\u00a0Tegaderm\u2122 Matrix were evaluated weekly and biopsied every two weeks until healed. At six weeks, the wounds showed clinically healthy wound beds and reduced inflammation. Histological changes were obvious in all biopsies. Immunohistochemical measurement of MMP-2 expression paralleled clinical characteristics of wound healing. Assessment of fibroblast MMP-2 expression reliably indicates wound healing with Tegaderm\u2122 Matrix treatment.<\/p><p dir=\"ltr\"><strong>Hampton Study<\/strong><\/p><p dir=\"ltr\">Hampton SL et al. \u201cAn observational study of the use of a polyhydrated ionogens impregnated dressing (DerMax\u00ae )* in the treatment of wounds.\u201d EWMA, Prague, Czech Republic, May 2006, poster presentation.<\/p><p dir=\"ltr\">Complex non-healing wounds\u00a0\u2022 Healing rate<br \/>\u2022 Reduction in wound size<\/p><p dir=\"ltr\">Observational study of 23 patients with a variety of complex wounds not healed after more than three months. Following treatment with Tegaderm\u2122 Matrix, overall healing rate at six weeks was 48%. Predicted potential healing rate if used for more than six weeks = 72%. A significant reduction in average wound size was found following treatment with Tegaderm\u2122 Matrix.<\/p><p dir=\"ltr\"><strong>Van Leen Study<\/strong><\/p><p dir=\"ltr\">Van Leen MWF et al. \u201cA prospective randomized study in recalcitrant pressure ulcers with polyhydrated ionogens is feasible.\u201d WUWHS, Paris, July 2004, poster presentation.<\/p><p dir=\"ltr\">Pressure ulcers\u00a0Standard debridement<br \/>\u2022 Wound closure<\/p><p dir=\"ltr\">Prospective, randomized study to determine the potential efficacy of PHI in treating a variety of pressure ulcers. Patients from nursing homes with stage II (n=1), III (n=10) and IV (n=8) pressure ulcers were treated until full wound closure or for six weeks, if no change was observed. Tegaderm\u2122 Matrix treatment resulted in full closure for 100% of stage II and stage III pressure ulcers with an average healing time of less than six weeks. Healing was reached in only 12.5% of stage IV ulcers (20% if dropouts are excluded). No adverse events or side effects were observed. Visual observations revealed that wounds became covered in a thin layer of transparent wound fluid. These exudates diminished as the wound healed during the course of treatment.<\/p><p dir=\"ltr\"><strong>Pirayesh Study<\/strong><\/p><p dir=\"ltr\">Pirayesh A et al. \u201cEfficacy of polyhydrated ionogens in achieving stable wound closure in recalcitrant diabetic foot ulcers: a multicentre pilot study.\u201d WUWHS, Paris, July 2004, oral presentation.<\/p><p dir=\"ltr\">Recalcitrant diabetic foot ulcers\u00a0Wound debridement<br \/>\u2022 Wound closure<br \/>\u2022 Patient satisfaction<\/p><p dir=\"ltr\">Multicentre, pilot study of 20 patients with diabetic foot ulcers &gt;2 cm2 with a duration of at least three months. Wounds (Wagner grade or stage I or II) were debrided and assessed weekly. Serum samples and random punch biopsies were taken on three occasions. Treatment with 3M\u2122\u00a0Tegaderm\u2122 Matrix resulted in high patient satisfaction and full closure in 75% of diabetic foot ulcers with an average healing time of 15 weeks. No adverse events or side effects were observed. Dressing changes were standardized. The ulcers were treated daily.<\/p><p dir=\"ltr\"><strong>Van den Berg Study<\/strong><\/p><p dir=\"ltr\">Van den Berg AJJ et al. \u201cA novel formulation of metal ions and citric acid reduces reactive oxygen species\u00a0in vitro.\u201d J Wound Care, Vol 12, Number 10, 2003..<\/p><p dir=\"ltr\">Non-healing wounds\u00a0\u2022 Action of metal ions<br \/>\u2022 Action of citric acid<\/p><p dir=\"ltr\">In vitro\u00a0study to investigate the activity of metal ions and citric acid in the reduction of reactive oxygen species. Metal ions inhibited PMNs (polymorphonuclear neutrophils) production of reactive oxygen species. Metal ions inhibited the activation of complement via the classical pathway. Citric acid was found to be a scavenger of superoxide anions.<\/p><h5 dir=\"ltr\">\u00a0<\/h5><p dir=\"ltr\"><strong>Schultz Study<\/strong><\/p><p dir=\"ltr\">Schultz GS et al. \u201cEffect of polyhydrated ionogens (PHI) on viability and matrix metalloproteinases levels in cultures of normal and diabetic human dermal fibroblasts.\u201d WHS, Chicago, May 2005, poster presentation.<\/p><p dir=\"ltr\">Cell culture, dermal fibroblasts\u00a0In vitro\u00a0study \u2013 Polyhydrated ionogens (PHI)<br \/>\u2022 Toxicity<br \/>\u2022 Changes in gene expression<\/p><p dir=\"ltr\">Study examines the cytoxicity of PHI and its effect on gene expression for MMP-2 and TIMPs. No toxicity was shown in dermal fibroblasts from a diabetic foot ulcer with PHI at concentrations of 0.02% to 1.25%. At higher concentrations (2.5%, 5% and 10%), cell numbers were reduced. No toxicity was shown in dermal fibroblasts from a normal volunteer at concentrations of 0.5% or lower. PHI has no toxicity at &lt;0.5% in cultures of fibroblasts from normal or diabetic patients. PHI induced similar changes of gene expression in normal and diabetic fibroblasts. PHI decreased MMP-2, mRNA and increased TIMP mRNA levels, in line with results found in clinical studies. Gene expression patterns are different in fibroblast cultures taken from normal and diabetic patients.<\/p><p dir=\"ltr\"><strong>Hoekstra &amp; Richters Study<\/strong><\/p><p dir=\"ltr\">Hoekstra MJ &amp; Richters N. et al. \u201cWound bed preparation, skin transplantation and matrix metalloproteinases.\u201d 11th International Conference on Tissue Banking, EATB Annual Meeting, October 2002, oral presentation.<\/p><p dir=\"ltr\">Skin grafting\u00a0In vivo\u00a0study<br \/>\u2022 MMP changes<br \/>\u2022 Inflammation<br \/>\u2022 Wound healing<\/p><p dir=\"ltr\">Down-regulation of MMP-2 (gelatinase A) diminishes breakdown of type IV collagen. MMP-9 appears to be associated with an active epithelialization process. A reduced inflammatory state is observed with reduced production of oxygen radicals by granulocytes with scavenging of oxygen radicals. Transformation of a non-healing wound into a healthy one takes place within two weeks of commencement of treatment with 3M\u2122\u00a0Tegaderm\u2122 Matrix.<\/p><h5 dir=\"ltr\">\u00a0<\/h5><p dir=\"ltr\"><strong>Hoekstra Study<\/strong><\/p><p dir=\"ltr\">Hoekstra MJ et al. \u201cPolyhydrated ionogens regulate matrix metalloproteinases expression and reactive oxygen (ROS) species production in recalcitrant wounds.\u201d Abstract from the European Tissue Repair Society Meeting, Amsterdam, September 2003, oral presentation.<\/p><p dir=\"ltr\">Experimental wounds\u00a0Skin transplantation \u2013 Polyhydrated ionogens (PHI)<br \/>\u2022 MMP expression<br \/>\u2022 ROS production<\/p><p dir=\"ltr\">Dressings were applied daily. Levels of MMP and ROS estimated in vitro through histological staining. Within two weeks, MMP-2 expression was down-regulated and re-epithelialization was initiated. Impaired healing in recalcitrant wounds is related to MMP\/TIMP imbalance and protracted inflammation. Protracted inflammation is associated with presence of reactive oxygen species (ROS). PHI regulates protease imbalance, down-regulates ROS production and stimulates re-epithelialization.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca248cc elementor-widget elementor-widget-spacer\" data-id=\"ca248cc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-605bfc6e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"605bfc6e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-861d61c elementor-invisible\" data-id=\"861d61c\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13fd2267 elementor-widget elementor-widget-image\" data-id=\"13fd2267\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/template5.thinkcreativeintelligence.com\/wp-content\/uploads\/2025\/04\/woman-holding-research-at-the-laboratory-1024x683.jpg\" 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https:\/\/template5.thinkcreativeintelligence.com\/wp-content\/uploads\/2025\/04\/pathology-laboratory-768x512.jpg 768w, https:\/\/template5.thinkcreativeintelligence.com\/wp-content\/uploads\/2025\/04\/pathology-laboratory.jpg 1080w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-64c51cba\" data-id=\"64c51cba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-72dd48a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"72dd48a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-41c4d81c\" data-id=\"41c4d81c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-43b57c6f elementor-widget elementor-widget-elementskit-heading\" data-id=\"43b57c6f\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Quick Links<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider\"><div 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Us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Summary of Studies Studies in down-regulating MMP levels Regenerex QBx\u2122 technology helps to normalize the micro-environment of wound beds by reducing protease levels, including MMP levels. This also applies to preceding generation PHI\u2122 technology referenced in some studies. Once the wound bed\u2019s microenvironment is normalized, the body\u2019s normal, natural healing process is able to regenerate [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-494","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/pages\/494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/comments?post=494"}],"version-history":[{"count":40,"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/pages\/494\/revisions"}],"predecessor-version":[{"id":1411,"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/pages\/494\/revisions\/1411"}],"wp:attachment":[{"href":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/wp-json\/wp\/v2\/media?parent=494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}