{"id":347,"date":"2025-07-25T02:24:21","date_gmt":"2025-07-25T02:24:21","guid":{"rendered":"https:\/\/template5.thinkcreativeintelligence.com\/?page_id=347"},"modified":"2025-08-21T15:19:43","modified_gmt":"2025-08-21T15:19:43","slug":"diabetic-foot-ulcers","status":"publish","type":"page","link":"https:\/\/template5.thinkcreativeintelligence.com\/index.php\/diabetic-foot-ulcers\/","title":{"rendered":"Diabetic Foot Ulcers"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"347\" class=\"elementor elementor-347\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1dbec7d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1dbec7d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1e4797d3\" data-id=\"1e4797d3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c5ad750 elementor-widget elementor-widget-heading\" data-id=\"c5ad750\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Diabetic Foot Ulcers<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1385cc2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1385cc2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-4bd9083\" data-id=\"4bd9083\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3edbf046 elementor-widget elementor-widget-elementskit-heading\" data-id=\"3edbf046\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Diabetic Foot Ulcers (DFU)<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider\"><div class=\"elementskit-border-divider\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5594c522 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5594c522\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2d462bb2\" data-id=\"2d462bb2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-222b7a97 elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"222b7a97\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/template5.thinkcreativeintelligence.com\/wp-content\/plugins\/elementor\/assets\/css\/widget-icon-list.min.css\">\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Approximately 19-34% of U.S. adults with diabetes develop DFUs in their lifetime<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Approximately 15% of people with diabetes will develop a foot ulcer and it is estimated that more than half of these will experience a second ulcer<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b5857af\" data-id=\"b5857af\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f18f1ce elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"5f18f1ce\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Up to 70% of all non-traumatic, major lower limb amputations are performed on diabetic patients<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-checkmark\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">The 5-year mortality after amputation in diabetes patients ranges from 39%-68%<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d2e143 elementor-widget elementor-widget-spacer\" data-id=\"6d2e143\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfecf39 elementor-widget elementor-widget-elementskit-heading\" data-id=\"cfecf39\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Diabetic Foot Ulcers Becoming Chronic<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35c9a5d9 elementor-widget elementor-widget-text-editor\" data-id=\"35c9a5d9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><span style=\"font-weight: 400;\">Diabetic foot ulcers, like other types of wounds, become chronic when they fail to progress through a normal, orderly, and timely sequence of repair, leading to stalled or delayed healing for weeks, months, and even years, and by a resistance to treatment with conventional dressings and therapies.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\">This persistence is often exacerbated in diabetic patients due to underlying factors specific to the disease, such as neuropathy (nerve damage) which can mask pain and delay detection, and peripheral artery disease (PAD) which impairs blood flow to the feet.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">Furthermore, chronic diabetic foot ulcers are also subject to the same general characteristics of chronic wounds, including increased levels of proteases (MMP-2 and MMP-9) that degrade the extracellular matrix and inactivate growth factors, and persistent overproduction of reactive oxygen species (ROS), all of which actively hinder the healing process. Therefore, when these ulcers fail to heal despite standard care and exhibit the biochemical hallmarks of chronicity, they are considered chronic wounds.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-194d0ee0 elementor-widget elementor-widget-spacer\" data-id=\"194d0ee0\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcfa0af elementor-widget elementor-widget-elementskit-heading\" data-id=\"bcfa0af\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Background<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce13fa elementor-widget elementor-widget-text-editor\" data-id=\"9ce13fa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Diabetic foot ulcers (DFUs) are open sores that develop on the feet of individuals with diabetes. They are a significant health burden, leading to substantial costs and a reduction in the quality of life for affected patients.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\">Diabetic foot ulcers are a significant problem on a global basis. Approximately 15% of people with diabetes will develop a foot ulcer and it is estimated that more than half of these will experience a second ulcer. Diabetic foot ulcers occur most commonly due to neuropathy (loss of sensation in the lower extremity) and peripheral vascular disease. Neuropathy can occur partially as a complication of prolonged glucose elevation (Steed 2007) Failure of diabetic foot ulcers to heal may result in amputation.<\/span><\/p><p><span style=\"font-weight: 400;\">The main reasons for diabetic foot ulcers failing to heal are two-fold. One primary cause is that the person with the foot ulcer continues to walk on the ulcer causing irritation and skin breakdown. They may also have some type of foreign body enter the skin and be unaware of this happening. For the healing process to take place, these wounds usually have weight redistributed away from the wound in what is known as offloading. Specialty shoes and devices are available to assist with this process.<\/span><\/p><p><span style=\"font-weight: 400;\">The second main reason that these ulcers fail to heal is related to proper diabetes control. Uncontrolled blood sugar can prevent the body from healing itself by preventing certain healing process from occurring. Management includes prevention of weight bearing (off loading) , debridement of devitalized tissue, prevention of infection and local wound management.<\/span><\/p><p><span style=\"font-weight: 400;\">DFUs are the most common cause for hospitalization of patients with diabetes. Approximately 19-34% of U.S. adults with diabetes develop DFUs in their lifetime. Up to 70% of all non-traumatic, major lower limb amputations are performed on diabetic patients, amounting to about 82,000 limb amputations each year. The 5-year mortality after amputation in diabetes patients ranges from 39%-68%.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60756cf elementor-widget elementor-widget-spacer\" data-id=\"60756cf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba07700 elementor-widget elementor-widget-elementskit-heading\" data-id=\"ba07700\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Diabetic Foot Ulcer Causes and Risk Factors<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62772c9 elementor-widget elementor-widget-text-editor\" data-id=\"62772c9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">These ulcers occur due to a combination of factors common in diabetes, including:<\/span><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Neuropathy (nerve damage):<\/b><span style=\"font-weight: 400;\"> High blood sugar levels can damage nerves, particularly in the feet, leading to a loss of sensation. This means patients may not feel pain from minor injuries, cuts, or blisters, allowing them to worsen without detection.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Peripheral Artery Disease (PAD):<\/b><span style=\"font-weight: 400;\"> Diabetes can cause atherosclerosis, narrowing or blocking arteries and reducing blood flow to the feet. This impaired circulation deprives tissues of oxygen and nutrients, hindering healing and increasing the risk of tissue death and ulcer formation.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Impaired immune function:<\/b><span style=\"font-weight: 400;\"> Diabetes can weaken the immune system, making individuals more susceptible to infections in wounds.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Structural foot deformities:<\/b><span style=\"font-weight: 400;\"> Long-term diabetes can lead to changes in foot shape, creating pressure points that are prone to breakdown.<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-586d5b1 elementor-widget elementor-widget-spacer\" data-id=\"586d5b1\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b18020 elementor-widget elementor-widget-elementskit-heading\" data-id=\"4b18020\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Characteristics of Diabetic Foot Ulcers<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-888062c elementor-widget elementor-widget-text-editor\" data-id=\"888062c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Location:<\/b><span style=\"font-weight: 400;\"> Often found on the bottom of the foot, especially under pressure points like the big toe, ball of the foot, or heel.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Appearance:<\/b><span style=\"font-weight: 400;\"> Can vary, but may have a &#8220;punched-out&#8221; appearance. The surrounding skin may be calloused due to repetitive trauma.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Pain:<\/b><span style=\"font-weight: 400;\"> Often painless due to neuropathy, which can delay diagnosis and treatment.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Infection:<\/b><span style=\"font-weight: 400;\"> Highly susceptible to infection, which can spread rapidly and lead to major tissue destruction and amputation.<\/span><\/li><\/ul><p><span style=\"font-weight: 400;\">Successful treatment of diabetic ulcers is challenging because they are difficult to heal and closure is often unstable. Treatment typically involves surgical debridement, adequate off-loading (reducing pressure on the ulcer), and moist wound healing.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\">Chronic diabetic foot ulcers are characterized by stalled or delayed healing, resistance to conventional therapies, increased levels of proteases (like MMP-2 and MMP-9), and persistent overproduction of reactive oxygen species (ROS), all of which impede the healing process.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8123bea elementor-widget elementor-widget-spacer\" data-id=\"8123bea\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4723f89b elementor-widget elementor-widget-elementskit-heading\" data-id=\"4723f89b\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Our Research<\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider elementskit-style-long\"><div class=\"elementskit-border-divider elementskit-style-long\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b4f87a9 elementor-widget elementor-widget-text-editor\" data-id=\"5b4f87a9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Regenerex is continuously evaluating new technologies to improve 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class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Need help?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-366299ff elementor-widget elementor-widget-text-editor\" data-id=\"366299ff\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>If you have questions regarding diabetic foot ulcers and how Regenerex technology can help the healing process, please contact us.\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5940ef93 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"5940ef93\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link 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lower limb amputations 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